Acknowledge the facility in publications: scientific papers, posters, Bachelor-, Master- or doctoral theses and contributions to conferences, is the only mean to prove the impact of the facility and the effective use of the equipment and are therefore needed for successful evaluation processes of the facility and for grant applications.

All publications or any data acquired or processed using LMF MDIBL equipment and/or services must be acknowledged in the appropriate way in every publication as follows:

“Images were acquired using equipment of the Light Microscopy Facility at the MDIBL, which is supported by the Maine INBRE grant (GM103423) from the National Institute of General Medical Sciences at the National Institutes of Health.

Assistance above the technical or routine level, with any facility staff providing scientific input and expertise in experimental set-up, acquisition or analysis, should be recognized through co-authorship on resulting publications. Please discuss acknowledgments with facility staff prior to manuscript submission.

If required, facility staff may be asked to review the sections describing the microscopy methods in drafts of publications. After publication, facility users are requested to provide a PDF-file of the publication for the facility’s records.

Source: Royal Microscopical Society and BioImaging UK



Adamla F, Rollins J, Newsom M, Snow S, Schosserer M, Heissenberger C, Horrocks J, Rogers AN, Ignatova Z. A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging. Cell Physiol Biochem [Internet]. 2019;52(5):970–983.

Grendler J, Lowgren S, Mills M, Losick VP. Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage. Development [Internet]. 2019;146(15).

Lan J, Rollins JA, Zang X, Wu D, Zou L, Wang Z, Ye C, Wu Z, Kapahi P, Rogers AN, Chen D. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep [Internet]. 2019;28(4):1050-1062.e6.

Mahringer A, Bernd A, Miller DS, Fricker G. Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. Biol Chem [Internet]. 2019;400(10):1335–1345.

Marnik EA, Fuqua JH, Sharp CS, Rochester JD, Xu EL, Holbrook SE, Updike DL. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Genetics [Internet]. 2019;213(3):923–939.

Müller-Deile J, Schenk H, Schroder P, Schulze K, Bolaños-Palmieri P, Siegerist F, Endlich N, Haller H, Schiffer M. Circulating factors cause proteinuria in parabiotic zebrafish. Kidney Int [Internet]. 2019;96(2):342–349.

Müller-Deile J, Schenk H, Niggemann P, Bolaños-Palmieri P, Teng B, Higgs A, Staggs L, Haller H, Schroder P, Schiffer M. Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy. Biol Open [Internet]. 2019 Mar 4;8(3).

Schenk H, Müller-Deile J, Schroder P, Bolaños-Palmieri P, Beverly-Staggs L, White R, Bräsen JH, Haller H, Schiffer M. Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep [Internet]. 2019;9(1):17718.

Schenk H, Masseli A, Schroder P, Bolaños-Palmieri P, Beese M, Hegermann J, Bräsen JH, Haller H. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Biomed Res Int [Internet]. 2019;2019:4508048.

Smith AM, Dykeman CA, King BL, Yin VP. Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration. iScience [Internet]. 2019 May 31;15:1–15.

Tossidou I, Teng B, Worthmann K, Müller-Deile J, Jobst-Schwan T, Kardinal C, Schroder P, Bolanos-Palmieri P, Haller H, Willerding J, Drost DM, de Jonge L, Reubold T, Eschenburg S, Johnson RI, Schiffer M. Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex. J Am Soc Nephrol [Internet]. 2019;30(7):1220–1237.

Beck S, Rhee C, Song J, Lee B-K, LeBlanc L, Cannon L, Kim J.”> Implications of CpG islands on chromosomal architectures and modes of global gene regulation. Nucleic Acids Res [Internet]. 2018;46(9):4382–4391.

Hersh TA, Dimond AL, Ruth BA, Lupica N V, Bruce JC, Kelley JM, King BL, Lutton B V. A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea. Am J Physiol Regul Integr Comp Physiol [Internet]. 2018;315(2):R218–R229.

Müller-Deile J, Schröder P, Beverly-Staggs L, Hiss R, Fiedler J, Nyström J, Thum T, Haller H, Schiffer M. Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish. Sci Rep [Internet]. 2018;8(1):3621.

Neuman RI, van Kalmthout JAM, Pfau DJ, Menendez DM, Young LH, Forrest JN. AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias). Am J Physiol Cell Physiol [Internet]. 2018;314(4):C473–C482.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T, Huber TB. A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep [Internet]. 2018;23(8):2495–2508.

Waldron AL, Schroder PA, Bourgon KL, Bolduc JK, Miller JL, Pellegrini AD, Dubois AL, Blaszkiewicz M, Townsend KL, Rieger S. Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity. J Diabetes Complications [Internet]. 2018;32(3):249–257.

Yasuda-Yamahara M, Rogg M, Frimmel J, Trachte P, Helmstaedter M, Schroder P, Schiffer M, Schell C, Huber TB. FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Matrix Biol [Internet]. 2018;68–69:263–279.

Yin VP. In Situ Detection of MicroRNA Expression with RNAscope Probes. Methods Mol Biol [Internet]. 2018;1649:197–208.

Andralojc KM, Campbell AC, Kelly AL, Terrey M, Tanner PC, Gans IM, Senter-Zapata MJ, Khokhar ES, Updike DL. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet [Internet]. 2017;13(2):e1006611.

Duong M, Yu X, Teng B, Schroder P, Haller H, Eschenburg S, Schiffer M. Protein kinase C ϵ stabilizes β-catenin and regulates its subcellular localization in podocytes. J Biol Chem [Internet]. 2017;292(29):12100–12110.

Godwin JW, Debuque R, Salimova E, Rosenthal NA. Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape. NPJ Regen Med [Internet]. 2017;2.

Lisse TS, Rieger S. IKKα regulates human keratinocyte migration through surveillance of the redox environment. J Cell Sci [Internet]. 2017;130(5):975–988.

Müller-Deile J, Dannenberg J, Schroder P, Lin M-H, Miner JH, Chen R, Bräsen J-H, Thum T, Nyström J, Staggs LB, Haller H, Fiedler J, Lorenzen JM, Schiffer M. Podocytes regulate the glomerular basement membrane protein nephronectin by means of miR-378a-3p in glomerular diseases. Kidney Int [Internet]. 2017;92(4):836–849.

Rochester JD, Tanner PC, Sharp CS, Andralojc KM, Updike DL. PQN-75 is expressed in the pharyngeal gland cells of Caenorhabditiselegans and is dispensable for germline development. Biol Open [Internet]. 2017 Sep 15;6(9):1355–1363.

Rollins JA, Howard AC, Dobbins SK, Washburn EH, Rogers AN. Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants. J Gerontol A Biol Sci Med Sci [Internet]. 2017 Apr 1;72(4):473–480.

Smith AM, Maguire-Nguyen KK, Rando TA, Zasloff MA, Strange KB, Yin VP. The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues. NPJ Regen Med [Internet]. 2017;2:4.

Updike D. swt-3 transcripts are expressed in Z1/Z4 during embryogenesis and in the adult spermatheca. microPublication Biol [Internet]. 2017 Jul 20;2017.

Updike D. acdh-1 transcripts are expressed in the intestine. microPublication Biol [Internet]. 2017 Jul 20;2017.

Zaremba A, Miller DS, Fricker G. Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus). Toxicol Appl Pharmacol. 2017 Nov 1;334:88-99

Bodnar AG, Coffman JA. Maintenance of somatic tissue regeneration with age in short- and long-lived species of sea urchins. Aging Cell [Internet]. 2016;15(4):778–87.

Hartig EI, Zhu S, King BL, Coffman JA. Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation. Biol Open [Internet]. 2016 Aug 15;5(8):1134–41.

Howard AC, Rollins J, Snow S, Castor S, Rogers AN. Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans. Aging Cell [Internet]. 2016 Dec;15(6):1027–1038.

King BL, Shi LF, Kao P, Clusin WT. Calcium activated K+ channels in the electroreceptor of the skate confirmed by cloning. Details of subunits and splicing. Gene [Internet]. 2016 Mar 1;578(1):63–73.

King BL, Yin VP. A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration. PLoS One [Internet]. 2016;11(6):e0157106.

Korstanje R, Deutsch K, Bolanos-Palmieri P, Hanke N, Schroder P, Staggs L, Bräsen JH, Roberts ISD, Sheehan S, Savage H, Haller H, Schiffer M. Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol [Internet]. 2016 Nov;27(11):3271–3277.

Lee EC, Kim H, Ditano J, Manion D, King BL, Strange K. Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis. PLoS One [Internet]. 2016;11(4):e0154156.

Lisse TS, King BL, Rieger S. Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Sci Rep [Internet]. 2016 Feb 5;6:20328.

Lisse TS, Middleton LJ, Pellegrini AD, Martin PB, Spaulding EL, Lopes O, Brochu EA, Carter E V, Waldron A, Rieger S. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A [Internet]. 2016 Apr 12;113(15):E2189-98.

Losick VP, Jun AS, Spradling AC. Wound-Induced Polyploidization: Regulation by Hippo and JNK Signaling and Conservation in Mammals. PLoS One [Internet]. 2016;11(3):e0151251.

Rizzo F, Coffman JA, Arnone MI. An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo. Dev Biol [Internet]. 2016;416(1):173–186.

Telles CJ, Decker SE, Motley WW, Peters AW, Mehr AP, Frizzell RA, Forrest JN. Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis. Am J Physiol Cell Physiol [Internet]. 2016 Dec 1;311(6):C884–C894.

Teng B, Schroder P, Müller-Deile J, Schenk H, Staggs L, Tossidou I, Dikic I, Haller H, Schiffer M. CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes. Diabetes [Internet]. 2016 Dec;65(12):3667–3679.

Wu C-W, Deonarine A, Przybysz A, Strange K, Choe KP. The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet [Internet]. 2016 Oct;12(10):e1006361.

Yamada T, Krzeminski M, Bozoky Z, Forman-Kay JD, Strange K. Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel. Biophys J [Internet]. 2016 Nov 1;111(9):1876–1886.

Yamada T, Strange K. Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains. Biophys J [Internet]. 2016 Nov 1;111(9):1887–1896.

Yamada T, Wondergem R, Morrison R, Yin VP, Strange K. Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish. Physiol Rep [Internet]. 2016;4(19).

Zhao H, Rieger S, Abe K, Hewison M, Lisse TS. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization. Int J Mol Sci [Internet]. 2016 Nov 26;17(12).

Beauchemin M, Smith A, Yin VP. Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration. Development [Internet]. 2015 Dec 1;142(23):4026–37.

Campbell AC, Updike DL. CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline. Development [Internet]. 2015 May 15;142(10):1745–55.

Carrier TJ, King BL, Coffman JA. Gene Expression Changes Associated With the Developmental Plasticity of Sea Urchin Larvae in Response to Food Availability. Biol Bull [Internet]. 2015 Jun;228(3):171–80.

Chen C-H, Merriman AF, Savage J, Willer J, Wahlig T, Katsanis N, Yin VP, Poss KD. Transient laminin beta 1a Induction Defines the Wound Epidermis during Zebrafish Fin Regeneration. PLoS Genet [Internet]. 2015 Aug;11(8):e1005437.

Hanke N, King BL, Vaske B, Haller H, Schiffer M. A Fluorescence-Based Assay for Proteinuria Screening in Larval Zebrafish (Danio rerio). Zebrafish [Internet]. 2015 Oct;12(5):372–6.

Kelly AL, Senter-Zapata MJ, Campbell AC, Lust HE, Theriault ME, Andralojc KM, Updike DL. A Forward Genetic Screen for Suppressors of Somatic P Granules in Caenorhabditis elegans. G3 (Bethesda) [Internet]. 2015 Jun 22;5(10):2209–15.

Lisse TS, Brochu EA, Rieger S. Capturing tissue repair in zebrafish larvae with time-lapse brightfield stereomicroscopy. J Vis Exp [Internet]. 2015 Jan 31;(95).

Madsen SS, Engelund MB, Cutler CP. Water transport and functional dynamics of aquaporins in osmoregulatory organs of fishes. Biol Bull. 2015;229(1):70-92.Biological Bulletin, 229 (1): 70-92

Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park J-K, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med [Internet]. 2015 Jun;21(6):601–9.

Schwarz JS, de Jonge HR, Forrest JN. Value of Organoids from Comparative Epithelia Models. Yale J Biol Med [Internet]. 2015 Dec;88(4):367–74.

Yang T, Martin P, Fogarty B, Brown A, Schurman K, Phipps R, Yin VP, Lockman P, Bai S. Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio. Pharm Res [Internet]. 2015 Jun;32(6):2003–14.